• Advanced Semen Analysis
  • Advanced Semen Analysis
  • Advanced Semen Analysis
  • Advanced Semen Analysis
  • Advanced Semen Analysis
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At-Home Tests

Advanced Semen Analysis

$440.00 USD
$489.00
$440.00 USD
For trying to conceive

For trying to conceive

DNA fragmentation can be elevated even when standard semen analysis parameters are within reference limits


  • Collect your sample at home and get a more complete clinical picture of your sperm health without a clinic visit. Advanced includes everything in Mate Health’s Comprehensive Semen Analysis, plus DNA Fragmentation Index (DFI) and sperm vitality testing. Every order includes a simplified patient report and physician lab report, plus MateIQ, Mate Health's AI report interpretation tool, which uses peer-reviewed andrology and fertility sources to help you better understand your results. Results are available within 24 hours of laboratory receipt.

    • 22 clinical semen parameters, including advanced diagnostics beyond our Comprehensive Semen Analysis
    • Adds DNA Fragmentation Index (DFI) and vitality (% live sperm)
    • Powered by Mate Health, a CLIA-certified, CAP-accredited high-complexity andrology laboratory
    • WHO 6th Edition semen examination methodology, a global standard
    • Validated Active Cooling specimen transport with FedEx Priority Overnight shipping
    • Not available in New York, Hawaii or Alaska

    Free shipping for US and Canada orders over $35. No duties. Discreet packaging.

    Advanced Semen Analysis
    Advanced Semen Analysis
    Advanced Semen Analysis
    Advanced Semen Analysis
    Advanced Semen Analysis

    How Mate Health Works

    Order your kit

    Order your kit

    Your at-home semen analysis kit ships in discreet packaging, no appointment or clinic visit required.
    Collect from home

    Collect from home

    Follow the simple instructions and collect in your own space, on your own schedule.
    Ship your sample

    Ship your sample

    Drop off your pre-labeled kit at FedEx. Your sample ships Priority Overnight to Mate Health’s CLIA-certified, CAP-accredited laboratory, while Active Cooling helps maintain it below 15Β°C for up to 34 hours in transit.
    Results + MateIQ

    Results + MateIQ

    Results are available within 24 hours of laboratory receipt through your secure portal, with MateIQ to help explain your report and prepare questions for your physician.

    Which test is right for you?

    At-Home Sperm Test Kit

    At-Home Sperm Test Kit

    Who it's for:

    • Couples trying or preparing to conceive who want a quick, at-home test and results
    • Couples who wish to do the testing at home, and not mail-in or in-clinic

    What it includes:

    • Everything you need to conduct collection and testing at home
    • Results sent to your smartphone within 20 minutes
    • Live sperm video you can share with your doctor

    What it tests:

    • 3 Core Semen Parameters: progressive motility, total motility, concentration
    • 2 Concentration Parameters: motile sperm concentration, progressive motile sperm concentration
    Shop Now - $99
    Comprehensive Semen Analysis

    Comprehensive Semen Analysis

    Who it's for:

    • Couples trying to conceive who want clinically detailed, physician-ready lab results, with sperm collection at home
    • Couples looking for a full motility breakdown (4 classifications), morphology, full sperm counts and functional sperm concentration

    What it includes:

    • Everything you need to conduct sample collection at home, plus Active Cooling transport packaging to help preserve your sample in transit
    • Results from a CLIA-certified, CAP-accredited high-complexity andrology laboratory within 24 hours of laboratory receipt
    • Simplified patient report, physician lab report, and microscopy images and videos for physician review
    • Access to MateIQ, Mate Health's AI report interpretation tool, to help you better understand your results

    What it tests:

    • All 5 parameters from the At-Home Sperm Test, measured in a clinical laboratory, plus 15 additional parameters, for 20 clinically relevant semen parameters in total:
    • 2 more Core Semen Parameters: volume and morphology
    • 3 more Concentration Parameters: rapid progressive motile sperm concentration, slow progressive motile sperm concentration and functional sperm concentration
    • 5 Counts Per Full Ejaculate Parameters: total sperm count, total motile sperm, progressive motile sperm, functional sperm, morphologically normal sperm
    • 4 Motility Classifications (rapidly progressive, slowly progressive, non-progressive, immotile), plus sperm velocity
    Shop Now - $249
    Advanced Semen Analysis

    Advanced Semen Analysis

    Who it's for:

    • Couples with unexplained infertility, recurrent pregnancy loss and/or preparing for IVF
    • Couples wanting the most complete clinical picture from day one, with sperm collection at home

    What it includes:

    • Everything you need to conduct sample collection at home, plus Active Cooling transport packaging to help preserve your sample in transit
    • Results from a CLIA-certified, CAP-accredited high-complexity andrology laboratory within 24 hours of laboratory receipt
    • Simplified patient report, physician lab report, and microscopy images and videos for physician review
    • Access to MateIQ, Mate Health's AI report interpretation tool, to help you better understand your results

    What it tests:

    • All 5 parameters from the At-Home Sperm Test, measured in a clinical laboratory, plus 17 additional parameters, for 22 clinically relevant semen parameters in total:
    • 2 Advanced Diagnostics: DNA Fragmentation Index (DFI) and sperm vitality (% live sperm)
    • 2 more Core Semen Parameters: volume and morphology
    • 3 more Concentration Parameters: rapid progressive motile sperm concentration, slow progressive motile sperm concentration and functional sperm concentration
    • 5 Counts Per Full Ejaculate Parameters: total sperm count, total motile sperm, progressive motile sperm, functional sperm, morphologically normal sperm
    • 4 Motility Classifications (rapidly progressive, slowly progressive, non-progressive, immotile), plus sperm velocity
    Shop now - $440

    Not sure where to start?

    The Bird&Be At-Home Sperm Test is the perfect first step to understanding male fertility

    • Over 97% accurate
    • FDA-cleared and doctor-recommended
    • Includes 3 tests so you can track improvements over time
    Shop Now

    FAQ

    What is DNA fragmentation and why does it matter?
    DNA fragmentation measures the percentage of sperm with damaged genetic material. High fragmentation levels are associated with reduced fertility, increased miscarriage risk, failed IVF cycles, and potential developmental issues. DNA damage can exist even when standard sperm parameters such as count, motility, and morphology appear normal, making it an important marker for couples experiencing unexplained infertility or recurrent pregnancy loss.
    What is the difference between comprehensive and advanced semen analysis?
    The advanced semen analysis includes everything in the comprehensive test (20+ parameters such as sperm count, motility, and morphology) plus DNA Fragmentation Index (DFI) testing. DNA fragmentation analysis identifies sperm with damaged genetic material that may impact fertilization success and embryo developmentβ€”issues that standard semen analysis cannot detect.
    Who should get DNA fragmentation testing?
    DNA fragmentation testing is particularly useful for couples experiencing unexplained infertility despite normal semen parameters, couples with recurrent miscarriages, men undergoing IVF or ICSI procedures, couples with previous failed IVF cycles, men over 40, smokers, or those exposed to environmental toxins or excessive heat.
    Can DNA fragmentation be improved?
    Yes. Unlike genetic mutations, DNA fragmentation is often reversible. Antioxidant supplementation, lifestyle changes such as reducing alcohol and quitting smoking, treating underlying medical conditions, reducing heat exposure, and improving overall health can help reduce fragmentation levels over time. Improvements are typically seen within 2–3 months.
    How is DNA fragmentation measured?
    DNA fragmentation is measured using specialized laboratory testing that evaluates the integrity of sperm DNA. Results are reported as a DNA Fragmentation Index (DFI), representing the percentage of sperm with damaged DNA.
    What is considered a normal DNA fragmentation level?
    DFI below 15% is considered optimal, 15–25% indicates moderate fragmentation that may affect fertility, 25–30% suggests high fragmentation associated with reduced fertility outcomes, and values above 30% are strongly associated with infertility and poor IVF outcomes.
    Can normal sperm count but high DNA fragmentation cause infertility?
    Yes. Some individuals have normal sperm count, motility, and morphology but elevated DNA fragmentation. This can lead to fertilization failure, embryo development issues, implantation failure, or miscarriage even when standard semen analysis appears normal.
    Does DNA fragmentation affect IVF success rates?
    Yes. High sperm DNA fragmentation has been associated with reduced IVF success rates, lower embryo quality, reduced implantation rates, and increased miscarriage risk. In some cases, fertility specialists may recommend techniques such as ICSI or sperm selection to improve outcomes.
    What causes sperm DNA fragmentation?
    Common causes include oxidative stress, smoking, alcohol consumption, obesity, environmental toxins, advanced paternal age, varicocele, high testicular temperature, infections, chronic inflammation, and certain medications or medical treatments.
    Should we pursue IVF if DNA fragmentation is high?
    High DNA fragmentation does not necessarily prevent IVF success, but it may require specialized approaches. A reproductive specialist may recommend lifestyle changes, antioxidant therapy, ICSI with sperm selection techniques, or other treatment options depending on your individual situation.
    How long does advanced semen analysis take?
    Results are typically available within 1–2 business days after the laboratory receives your sample. The advanced analysis includes both standard semen parameters and DNA fragmentation results delivered through a secure online portal.
    Is the advanced test worth the additional cost?
    The advanced test may be worthwhile for individuals with unexplained infertility, recurrent miscarriages, failed fertility treatments, or risk factors for DNA damage. Identifying DNA fragmentation early can help guide treatment decisions and potentially avoid unsuccessful fertility treatments.
    If my partner has had multiple miscarriages, should I get this test?
    Yes. Elevated sperm DNA fragmentation has been linked to recurrent pregnancy loss, even when standard semen parameters appear normal. Testing can help identify whether sperm DNA damage may be contributing to miscarriages.
    We've done IVF twice with no successβ€”will this test help?
    In some cases, repeated IVF failure may be linked to sperm DNA fragmentation affecting embryo development or implantation. Advanced semen analysis can provide additional diagnostic insight before pursuing further fertility treatments.
    I'm over 40β€”should I consider the advanced test?
    Yes. DNA fragmentation tends to increase with paternal age, particularly after 40. Even when sperm count and motility remain normal, DNA quality may decline, making advanced testing useful for a more complete fertility assessment.
    Can I have normal comprehensive results but abnormal advanced results?
    Yes. Some individuals have normal sperm count, motility, and morphology but elevated DNA fragmentation. This situation is sometimes referred to as unexplained infertility and is one of the primary reasons advanced testing exists.
    How often should DNA fragmentation be retested?
    Retesting is typically recommended 2–3 months after implementing lifestyle or medical interventions, since the sperm production cycle takes approximately 74 days.
    Is collection different for the advanced test?
    No. Sample collection is the same as the comprehensive test: abstain for 2–5 days and collect the full semen sample at home using the provided sterile container.
    Can medications affect DNA fragmentation results?
    Yes. Certain medicationsβ€”including anabolic steroids, chemotherapy drugs, testosterone therapy, and some antibioticsβ€”may affect sperm DNA integrity. If you are taking medications, consult with your healthcare provider before testing.
    Does insurance cover DNA fragmentation testing?
    Insurance coverage varies by provider and plan. Some insurers cover the test when ordered by a physician as part of infertility evaluation, while others do not. However, the test is generally eligible for HSA and FSA payment.
    What antioxidants help reduce DNA fragmentation?
    Research-supported antioxidants include CoQ10, vitamin C, vitamin E, selenium, zinc, L-carnitine, and N-acetylcysteine (NAC). These may help reduce oxidative stress that contributes to DNA damage.
    Will this test tell me whether I need IVF or ICSI?
    The test provides diagnostic information that helps fertility specialists determine the most appropriate treatment approach. Results should be interpreted alongside other fertility factors, including female partner health and previous treatment history.
    How does DNA fragmentation affect embryo quality?
    High DNA fragmentation can negatively affect embryo development, increasing the likelihood of poor embryo quality, implantation failure, or miscarriageβ€”even when embryos initially appear normal.
    Can I upgrade from comprehensive to advanced testing later?
    No. DNA fragmentation testing must be performed on the original semen sample. If you initially choose comprehensive testing and later want DNA fragmentation analysis, you would need to order a new advanced test kit.