If you’re taking a prenatal when trying to conceive that includes CoQ10 in its formula—like our Power Prenatal for Females—you may be wondering if it’s safe to continue once you get that positive pregnancy test.
- What is CoQ10?
- How does CoQ10 affect fertility and pregnancy?
- Is taking CoQ10 safe during pregnancy?
- Are there risks or side effects?
- Can CoQ10 help lower the risk of preeclampsia?
- Can CoQ10 help lower the risk of cholestasis?
What is CoQ10?
CoQ10 is an antioxidant that, along with fighting against free-radical damage, promotes the repair and growth of tissue, making it an excellent source of energy for both eggs and sperm.
Read more about CoQ10 →
How does CoQ10 affect fertility and pregnancy?
CoQ10 is widely recommended as a fertility booster because research shows it can improve pregnancy outcomes. Fertility doctors typically recommend supplementing with CoQ10 (at the recommended 600 mg per day dose) when trying to conceive or during fertility treatment because there are lots of studies to back up its effects on egg and sperm quality. Taking CoQ10 supplements at the research-backed dose can increase the amount of energy produced by eggs, making them better candidates for becoming a healthy embryo. Once eggs are fertilized, they divide and multiply rapidly. This requires a lot of energy, and CoQ10 helps make sure eggs are ready once fertilization happens.
Research about CoQ10 and pregnancy is ongoing. That's not unusual; doctors and researchers like to be sure a supplement or medication won't harm pregnancies before giving it the official green light and testing on pregnant people is often considered risky, even when the chances of negative outcomes are low (that’s why there are so many pregnancy rules, from what you can’t eat, to activities you can’t do—it’s better to be safe). Early trials suggest that CoQ10 is not harmful and it is potentially helpful in reducing the risk of pregnancy complications like cholestasis and preeclampsia.
But, there are some studies, and the research is promising—CoQ10 may affect fertility and pregnancy positively:
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CoQ10 may help organ growth during fetal development.
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CoQ10 can reduce oxidative stress, even in embryos, improving pregnancy outcomes.
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Supplementing with at least 250 mg of CoQ10 daily can reduce the risk of chromosomal defects in embryos.
The science is still evolving on CoQ10 pregnancy safety and how to use CoQ10 during pregnancy.
Fertility doctors typically recommend supplementing with CoQ10 (at up to 600 mg per day) when trying to conceive or during fertility treatment because there are lots of studies to back up its effects on egg and sperm quality.
Is taking CoQ10 safe during pregnancy?
CoQ10 is well-studied and has a great safety record as a daily supplement. And, there are no links between the supplement and negative outcomes in pregnancy—in fact some preliminary research suggests it could be helpful for some individuals (see some recent findings, above). Importantly, there are no known connections between CoQ10 use during pregnancy and miscarriage. But, since we don’t have too many studies of CoQ10 during pregnancy, most doctors don’t currently recommend it as a stand-alone supplement if you are pregnant. Plus, you may opt to simplify your supplement routine once you confirm your pregnancy.
Are there risks or side effects of CoQ10 use while pregnant?
Caution is recommended when taking CoQ10 while pregnant or if you are on blood thinners like warfarin, anisindione, or dicumarol. CoQ10 can make these medications less effective, increasing your risk for blood clots.
Our NDs recommend switching to The Complete Prenatal Pack (or the Gentle Prenatal Gummies if you’re battling morning sickness) once pregnant, and neither formula includes CoQ10. Make sure to always check in with your doctor and OB/GYN to determine what supplements will be best for you during your pregnancy.
Can CoQ10 help lower the risk of preeclampsia?
Preeclampsia is a serious pregnancy complication marked by a sharp increase in blood pressure during pregnancy. It develops after the 20th week of pregnancy, and it can lead to pre-term birth, maternal seizures, maternal organ damage, or even death.
The good news is that prenatal care, nutrition, and lifestyle choices can lower risks of serious complications from preeclampsia. Emerging research also suggests that taking CoQ10 supplements while pregnant may help reduce the likelihood of developing this dangerous condition.
CoQ10 may help lower the risk of preeclampsia, especially in females who are already considered high-risk. In one study, those who started taking 200 mg of CoQ10 per day at 20 weeks had a 44% lower rate of preeclampsia than women who didn't supplement with CoQ10. A 2025 study showed that higher CoQ10 levels in the placenta are associated with a lower risk of preeclampsia.
Can CoQ10 help lower the risk of cholestasis?
Cholestasis is a liver disorder that disrupts the flow of bile from the liver to the intestine, happening in the second or third trimester. It can cause uncomfortable symptoms (like itching) and lead to some potentially serious pregnancy complications because of the significant increase in oxidative stress, thanks to the accumulation of bile acids. Those risks include preterm delivery, fetal distress, and perinatal mortality. A study on cholestasis in pregnancy showed that lower CoQ10 in individuals who had the disorder, and another study suggests that CoQ10 supplementation may be a treatment option because of its ability to reduce damage from oxidative stress.
